| Date | Location | Result | |
| 2/27/01 | Clinton, S.C. (Ross E. Templeton Center) | Presbyterian 83, Tusculum College 47 | Box score |
| 2/24/01 | Greeneville, Tenn. (Alpine Arena) | Wingate 80, Tusculum College 59 | Box score |
| 2/21/01 | Mars Hill, N.C. (Stanford Arena) | Mars Hill 97, Tusculum College 83 | Box score |
| 2/17/01 | Jefferson City, Tenn. (Holt Fieldhouse) | Carson-Newman 77, Tusculum College 67 | Box score |
| 2/14/01 | Greeneville, Tenn. (Alpine Arena) | Tusculum College 74, Newberry 68 | Box score |
| 2/10/01 | Hickory, N.C. (Shuford Gym) | Lenoir-Rhyne 79, Tusculum College 55 | Box score |
| 2/7/01 | Greeneville, Tenn. (Alpine Arena) | Catawba 79, Tusculum College 59 | Box score |
| 2/3/01 | Greeneville, Tenn. (Alpine Arena) | Presbyterian 75, Tusculum College 48 | Box score |
| 1/31/01 | Greeneville, Tenn. (Alpine Arena) | Lincoln Memorial 77, Tusculum College 58 | Box score |
| 1/27/01 | Wingate, N.C. (Cuddy Arena) | Wingate 95, Tusculum College 76 | Box score |
| 1/24/01 | Greeneville, Tenn. (Alpine Arena) | Mars Hill 115, Tusculum College 76 | Box score |
| 1/20/01 | Greeneville, Tenn. (Alpine Arena) | Carson-Newman 67, Tusculum College 64 | Box score |
| 1/17/01 | Newberry, S.C. (Eleazer Arena) | Tusculum College 76, Newberry 56 | Box score |
| 1/13/01 | Greeneville, Tenn. (Alpine Arena) | Lenoir-Rhyne 72, Tusculum College 56 | Box score |
| 1/10/01 | Salisbury, N.C. (Goodman Gymnasium) | Catawba 96, Tusculum College 54 | Box score |
| 1/6/01 | Clinton, S.C. (Ross E. Templeton Center) | Presbyterian 92, Tusculum College 53 | Box score |
| 1/3/01 | Greeneville, Tenn. (Alpine Arena) | Tusculum College 74, Lees-McRae 67 | Box score |
| 12/11/00 | Wise, Va. (Greear Gymnasium) | Tusculum College 80, Virginia-Wise 70 | Box score |
| 12/9/00 | Athens, W.V. (Centennial Hall) | Concord 75, Tusculum College 66 | Box score |
| 12/7/00 | Greeneville, Tenn. (Alpine Arena) | Tusculum College 74, Bluefield State 54 | Box score |
| 12/5/00 | Tigerville, S.C. | Tusculum College 102, North Greenville 88 | Box score |
| 11/29/00 | Harrogate, Tenn. (Tex Turner Arena) | Lincoln Memorial 91, Tusculum College 74 | Box score |
| 11/27/00 | Greeneville, Tenn. (Alpine Arena) | Tusculum College 83, Concord 64 | Box score |
| 11/20/00 | Greeneville, Tenn. (Alpine Arena) | Tusculum College 86, Virginia-Wise 48 | Box score |
| 11/18/00 | Bluefield, W.V. (Ned Shott Gymnasium) | Concord 76, Tusculum College 69 | Box score |
| 11/17/00 | Bluefield State (Ned Shott Gymnasium) | Tusculum College 81, Bluefield State 73 | Box score |